Description

4-Acetamidophenyl-D3 B-D-Glucuronide is a high-purity, deuterium-labeled internal standard critical for advanced analytical quantification. This compound is specifically designed to ensure accuracy and reliability in mass spectrometry-based methods by compensating for matrix effects and instrument variability. It is an essential reagent for researchers and quality control laboratories in the pharmaceutical and contract research organization (CRO) sectors who require precise measurement of drug metabolites and related compounds.

Application

• Internal Standard for LC-MS/MS: Primary use as a quantitative internal standard in liquid chromatography-tandem mass spectrometry for pharmacokinetic and bioanalytical studies.
• Drug Metabolism Research: Enables accurate tracking and quantification of glucuronidated metabolites of acetaminophen (paracetamol) and related compounds in biological matrices.
• Biomarker Analysis: Supports the development and validation of assays for specific metabolic biomarkers in clinical and preclinical research.
• Pharmaceutical QA/QC: Used in quality control laboratories for method development and validation to ensure the accuracy of impurity and metabolite profiling.
• Toxicology Studies: Facilitates precise measurement of drug-related compounds in forensic and regulatory toxicology investigations.
• Stable Isotope Labeling: Serves as a key reference material in studies utilizing stable isotope dilution techniques for maximum analytical precision.

Basic Information

Product Name	4-Acetamidophenyl-D3 B-D-Glucuronide
CAS No.	1260619-62-2
Molecular Formula	C₁₄H₁₂D₃NO₈
Molecular Weight	334.30 g/mol
Synonyms	4-Acetamidophenyl-D3 Glucuronide; Paracetamol-D3 Glucuronide (Deuterated); APAP-D3 Glucuronide; N-Acetyl-p-aminophenyl-D3 B-D-Glucuronide; 4'-Hydroxyacetanilide-D3 Glucuronide; Deuterated Acetaminophen Glucuronide; 1-O-(4-Acetamidophenyl-2,3,5,6-D3)-B-D-Glucopyranuronic Acid
EINECS	Contact for details

Quality Control

Every batch of 4-Acetamidophenyl-D3 B-D-Glucuronide is manufactured and tested under strict quality management systems to ensure the highest standards of purity and isotopic enrichment required for analytical applications. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, isotopic purity (D-enrichment), and analytical data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after use to prevent degradation from atmospheric moisture. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (D-enrichment)	≥98 atom % D
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.