Description

4-Acetamidophenyl B-D-Glucuronide-D3, Sodium Salt is a high-purity, deuterium-labeled internal standard critical for advanced analytical quantification. This compound is specifically designed for use in Liquid Chromatography-Mass Spectrometry (LC-MS) and related bioanalytical techniques, where it provides unmatched accuracy and reliability for metabolite studies. It is an essential reagent for pharmaceutical R&D, clinical research, and forensic toxicology laboratories focused on pharmacokinetics, drug metabolism, and biomarker discovery.

Application

• LC-MS/MS Internal Standard: Primary use as a quantitative reference standard for the accurate measurement of drug metabolites and related compounds in complex biological matrices.
• Pharmacokinetic & Metabolism Studies: Enables precise tracking and quantification of acetaminophen (paracetamol) metabolites in in vitro and in vivo research.
• Biomarker Research & Validation: Supports the development and validation of analytical methods for specific glucuronide-conjugated biomarkers in clinical samples.
• Forensic & Clinical Toxicology: Used in assays to confirm and quantify exposure to specific substances through their glucuronidated metabolic pathways.
• Drug Development & DMPK: Critical tool in Drug Metabolism and Pharmacokinetics (DMPK) departments for ensuring data integrity in regulatory submissions.
• Quality Control in Reference Material Production: Serves as a calibrant or system suitability standard in the manufacturing of certified reference materials (CRMs).

Basic Information

Product Name	4-Acetamidophenyl B-D-Glucuronide-D3, Sodium Salt
CAS No.	1260619-61-1
Molecular Formula	C14H13D3NNaO8
Molecular Weight	370.29 g/mol (monoisotopic)
Synonyms	4-Acetamidophenyl β-D-Glucopyranosiduronic Acid-d3 Sodium Salt; Paracetamol Glucuronide-d3 Sodium Salt; APAP-Glucuronide-d3 Sodium Salt; N-Acetyl-p-aminophenyl Glucuronide-d3 Sodium Salt; 1-O-(4-Acetamidophenyl)-β-D-glucopyranuronic Acid-d3 Sodium Salt; Deuterated Acetaminophen Glucuronide Sodium Salt; (4-Acetamidophenyl) 2,3,4-Tri-O-acetyl-β-D-glucopyranosiduronic Acid-d3 Sodium Salt (precursor form)
EINECS	Contact for details

Quality Control

Every batch of our 4-Acetamidophenyl B-D-Glucuronide-D3, Sodium Salt is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, with comprehensive testing including NMR, HPLC, and MS to confirm structure, assay, and deuterium incorporation. Certificates of Analysis (COA) detailing batch-specific results are provided and traceable to relevant in-house standards. Our quality commitment supports compliance needs for GLP and GMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to expected m/z
Purity (HPLC)	≥ 95% (Chemical)
Isotopic Purity (Deuterium Incorporation)	≥ 98 atom % D
Assay (HPLC)	≥ 90% (on dried basis)
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.