Description

n-Acetyl-S-(2-Cyanoethyl)-L-Cysteine-D3 is a deuterium-labeled internal standard critical for advanced analytical chemistry. This compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry analyses, particularly in complex biological matrices. It is primarily used by researchers and quality control laboratories in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors for method development and validation.

Application

• Quantitative Bioanalysis: Serves as a stable isotope-labeled internal standard for the precise quantification of its non-deuterated counterpart or related metabolites in pharmacokinetic (PK) and toxicokinetic (TK) studies via LC-MS/MS.
• Biomarker Research: Enables accurate measurement of specific cysteine adducts or metabolic pathways in proteomics and metabolomics research for disease biomarker discovery.
• Drug Metabolism and Disposition (DMPK): Used in in vitro and in vivo studies to track drug metabolism, assess covalent binding, and investigate glutathione-related detoxification pathways with high precision.
• Toxicology and Safety Assessment: Facilitates the sensitive detection and quantification of electrophilic drug intermediates or toxicant adducts to biomolecules, supporting safety profiling.
• Method Validation and Regulatory Compliance: Critical for developing and validating GLP/GCP-compliant analytical methods that require isotope dilution for definitive accuracy in regulatory submissions.
• Reference Material Production: Acts as a certified reference material (CRM) for calibrating instruments and ensuring data integrity across laboratories.

Basic Information

Product Name	n-Acetyl-S-(2-Cyanoethyl)-L-Cysteine-D3
CAS No.	1260619-59-7
Molecular Formula	C8H10D3N2O3S
Molecular Weight	206.26 g/mol (for deuterated form)
Synonyms	N-Acetyl-S-(2-cyanoethyl)-L-cysteine-d3; N-Acetyl-3-[(2-cyanoethyl)thio]-L-alanine-d3; N-Acetyl-S-(2-cyanoethyl)cysteine-d3; Acetyl-S-(2-cyanoethyl)cysteine-d3; L-Cysteine, N-acetyl-S-(2-cyanoethyl)-, d3-; N-Acetyl-S-(β-cyanoethyl)-L-cysteine-d3; Deuterated N-Acetyl-SCNAC; Internal Standard for Cysteine Adduct Analysis-d3
EINECS	Contact for details

Quality Control

Our deuterated standards are produced under strict quality management systems to ensure the high isotopic purity and chemical integrity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) is provided, detailing isotopic enrichment (typically ≥98 atom % D), chemical purity (by HPLC), and identity confirmation. We support compliance with GMP/GLP guidelines for use in regulated studies.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This compound is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant or under inert atmosphere to maintain stability and isotopic integrity. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95.0%
Isotopic Purity (NMR/MS)	≥98 atom % D
Chemical Purity (by HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.