Description

4-Acetamidophenyl-D3-2,3,4-Tri-o-Acetyl--D-Glucuronide, Methyl Ester is a high-purity, deuterium-labeled chemical reference standard critical for advanced analytical applications. This compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry analyses, particularly in pharmacokinetic and metabolic studies. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers specializing in drug development and bioanalysis.

Application

• Internal Standard for LC-MS/MS: Serves as a stable, isotopically labeled internal standard for the precise quantification of drug metabolites and related compounds in complex biological matrices like plasma, serum, and urine.
• Pharmacokinetic (PK) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) by providing a non-interfering reference signal in mass spectrometric assays.
• Metabolite Identification & Profiling: Used as a reference material to identify and characterize glucuronidated metabolites of pharmaceuticals, aiding in understanding drug metabolism pathways.
• Bioanalytical Method Development & Validation: A key component in developing, optimizing, and validating robust, GLP-compliant analytical methods for regulatory submissions.
• Clinical Research & Toxicology: Supports studies investigating drug-drug interactions, therapeutic drug monitoring, and forensic toxicology analyses.
• Quality Control in Pharmaceutical Manufacturing: Can be utilized as a system suitability or calibration standard in quality control labs to ensure the consistency of analytical instrumentation.

Basic Information

Product Name	4-Acetamidophenyl-D3-2,3,4-Tri-o-Acetyl--D-Glucuronide, Methyl Ester
CAS No.	1260619-58-6
Molecular Formula	C21H22D3NO11
Molecular Weight	476.44 g/mol (calculated)
Synonyms	4-Acetamidophenyl-D3-2,3,4-Tri-O-acetyl-β-D-glucopyranosiduronic Acid Methyl Ester; Deuterated Acetaminophen Glucuronide Methyl Ester Triacetate (D3); Paracetamol-D3 Glucuronide Methyl Ester Triacetate; APAP-D3 Glucuronide Triacetate Methyl Ester; N-(4-Hydroxyphenyl)acetamide-D3 2,3,4-Tri-O-acetyl-β-D-glucopyranosiduronic Acid Methyl Ester; [2,3,4-Tri-O-acetyl-α/β-D-glucopyranuronosyl]-(1→O)-4-acetamidobenzene-D3 Methyl Ester; Deuterium Labeled Acetaminophen Glucuronide Derivative
EINECS	Contact for details

Quality Control

Every batch of 4-Acetamidophenyl-D3-2,3,4-Tri-o-Acetyl--D-Glucuronide, Methyl Ester is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity suitable for sensitive mass spectrometry applications. Our products undergo rigorous quality testing, including NMR, HPLC, and MS, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing batch-specific purity, isotopic enrichment, and analytical data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity (D3)	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 98%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.