Description

Abacavir-D4 is a deuterated internal standard of the nucleoside reverse transcriptase inhibitor Abacavir, specifically labeled with four deuterium atoms. This stable isotope-labeled compound is essential for ensuring the accuracy and precision of quantitative mass spectrometry analyses in pharmaceutical research and development. It is primarily used by analytical chemists and researchers in pharmaceutical, contract research, and clinical diagnostic laboratories for method development, validation, and bioanalytical studies.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard for the accurate LC-MS/MS quantification of Abacavir in complex biological matrices such as plasma, serum, and tissue homogenates.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables reliable tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical trials.
• Metabolite Identification and Profiling: Aids in distinguishing drug-derived metabolites from endogenous compounds in mass spectrometry-based metabolite screening.
• Method Development and Validation: Provides a stable reference point for developing robust, sensitive, and specific analytical methods compliant with FDA, EMA, and ICH guidelines.
• Quality Control in Manufacturing: Used in in-process testing and final product release assays to ensure the purity and potency of Abacavir-based pharmaceutical formulations.
• Forensic and Doping Control Analysis: Supports the definitive identification and quantification of Abacavir in forensic toxicology and anti-doping programs.

Basic Information

Product Name	Abacavir-D4
CAS No.	1260619-56-4
Molecular Formula	C14H14D4N6O
Molecular Weight	274.33 g/mol
Synonyms	(1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol-d4; Abacavir (D4); Abacavir-d4; (1S-cis)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol-d4; Cyclopropavir-d4; Ziagen-d4; ABC-d4; Deuterated Abacavir Internal Standard
EINECS	Contact for details

Quality Control

Every batch of Abacavir-D4 is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to support your regulatory submissions, including Certificates of Analysis (COA) with detailed results for identity, purity (by HPLC), isotopic enrichment, and residual solvents. Our quality protocols are designed to meet the stringent requirements of GMP/GLP environments for pharmaceutical reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D4)	≥98.0 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.