Description

Fmoc-3,4-Dichloro-D-Homophenylalanine CAS NO 1260618-71-0 is a high-purity, non-natural amino acid derivative specifically engineered for advanced peptide synthesis. This compound is a critical building block for medicinal chemists and researchers developing novel peptide-based therapeutics and diagnostic tools. It is primarily utilized in solid-phase peptide synthesis (SPPS) for the controlled introduction of a modified, halogenated phenylalanine analog into peptide chains, enabling the study of structure-activity relationships and the creation of targeted bioactive molecules.

Application

• Pharmaceutical Research & Development: A key intermediate in the synthesis of complex peptide drug candidates, particularly for oncology, metabolic disorders, and central nervous system (CNS) targets.
• Peptidomimetics Design: Used to incorporate a rigid, hydrophobic, and halogenated side chain into peptide backbones to enhance binding affinity, metabolic stability, and membrane permeability.
• Chemical Biology Probes: Essential for creating labeled or modified peptides used as tools to study protein-protein interactions, enzyme mechanisms, and cellular pathways.
• Antibody-Drug Conjugate (ADC) Linker/Payload Synthesis: Serves as a specialized component in the construction of peptide-based linkers or cytotoxic warheads for targeted cancer therapies.
• Process Development & Scale-Up: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the GMP-scale production of clinical trial materials and commercial APIs.
• Academic Research: Employed in university and institutional labs for fundamental studies in organic chemistry, peptide science, and medicinal chemistry.

Basic Information

Product Name	Fmoc-3,4-Dichloro-D-Homophenylalanine
CAS No.	1260618-71-0
Molecular Formula	C25H21Cl2NO4
Molecular Weight	470.34 g/mol
Synonyms	Fmoc-D-homo-Phe(3,4-Cl2)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3,4-dichloro-D-homophenylalanine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-(3,4-dichlorophenyl)pentanoic acid; Fmoc-3,4-DiCl-D-hPhe-OH; Fmoc-D-3,4-dichlorohomophenylalanine; N-Fmoc-3,4-dichloro-D-homophenylalanine; Fmoc-D-Hph(3,4-Cl2)-OH
EINECS	Contact for details

Quality Control

Every batch of Fmoc-3,4-Dichloro-D-Homophenylalanine is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We guarantee high chemical and chiral purity to meet the exacting standards of pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) providing results for identity, purity (HPLC), chiral purity, and related substances is provided with each shipment to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.