Description

Trandolapril Acyl--D-Glucuronide, 85% CAS NO 1260617-50-2 is a key metabolite of the ACE inhibitor Trandolapril, formed via hepatic glucuronidation. This compound is of significant value for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the development of bioanalytical methods. It is primarily required by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in advanced drug discovery and regulatory compliance activities.

Application

• Metabolite Reference Standard: Serves as a critical certified reference material (CRM) for the quantification of Trandolapril and its metabolites in biological matrices during preclinical and clinical studies.
• Pharmacokinetic & ADME Research: Used to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of Trandolapril, aiding in understanding its in vivo behavior.
• Bioanalytical Method Development: Essential for developing and validating sensitive analytical methods, such as LC-MS/MS, for therapeutic drug monitoring and regulatory submissions.
• Impurity Profiling: Acts as a characterized impurity standard in the quality control of Trandolapril active pharmaceutical ingredient (API) to ensure product purity and safety.
• Drug-Drug Interaction Studies: Utilized in studies to assess potential metabolic interactions when Trandolapril is co-administered with other medications.
• Toxicology and Safety Assessment: Employed in metabolite identification and safety studies to fulfill regulatory requirements for new drug applications.

Basic Information

Product Name	Trandolapril Acyl--D-Glucuronide, 85%
CAS No.	1260617-50-2
Molecular Formula	C29H40N2O11
Molecular Weight	592.64 g/mol
Synonyms	Trandolapril Acyl Glucuronide; Trandolapril Glucuronide Metabolite; (2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid β-D-Glucopyranosiduronic acid; Trandolapril 1-O-β-Acyl Glucuronide; Trandolapril Acyl-β-D-Glucuronide
EINECS	Contact for details

Quality Control

Our Trandolapril Acyl--D-Glucuronide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity confirmation and identity verification by spectroscopic methods (IR, NMR, MS). We provide comprehensive Certificates of Analysis (COA) detailing assay, impurity profile, and other critical parameters to ensure compliance with research and development standards. Specifications are aligned with the needs of pharmaceutical reference standard applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, ideally between 15-25°C (59-77°F). The product is light-sensitive (store away from light) and should be handled in a manner to minimize prolonged exposure to light and moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 85.0%
Related Substances (HPLC)	Total impurities ≤ 15.0% Any single unknown impurity ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.