Description

Alvimopan Acyl-β-D-Glucuronide is a key metabolite and reference standard of the peripherally-acting μ-opioid receptor antagonist, alvimopan. This compound is essential for pharmaceutical research and development, particularly in the study of drug metabolism and pharmacokinetics (DMPK). It is primarily used by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies involved in bioanalytical method development and regulatory compliance testing.

Application

• Pharmaceutical Reference Standard: Serves as a critical certified standard for the quantification of alvimopan metabolites in biological matrices during clinical and non-clinical studies.
• Drug Metabolism and Pharmacokinetics (DMPK) Research: Used to investigate the metabolic pathways, bioavailability, and excretion profiles of alvimopan.
• Bioanalytical Method Development: Essential for developing and validating sensitive HPLC-MS/MS or LC-UV methods for therapeutic drug monitoring and pharmacokinetic assays.
• Impurity Profiling and Characterization: Employed as an impurity marker to ensure the purity and safety of alvimopan active pharmaceutical ingredient (API) batches.
• Toxicology Studies: Used in studies to understand the safety and toxicity profile of alvimopan's major metabolites.
• Regulatory Submissions: Provides necessary data for filings with regulatory bodies like the FDA and EMA, supporting drug approval processes.

Basic Information

Product Name	Alvimopan Acyl-β-D-Glucuronide
CAS No.	1260616-95-2
Molecular Formula	C34H43N3O12
Molecular Weight	685.72 g/mol
Synonyms	Alvimopan Glucuronide; Alvimopan Acyl Glucuronide; ADL 8-2698 Glucuronide; (2S)-2-[[(2S)-2-[[(3R,4R)-4-(3-Hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]methyl]-3-phenylpropanoyl]amino]acetic acid β-D-Glucopyranosiduronic acid; LY246736 Glucuronide; 5-[[(2S)-2-[[(3R,4R)-4-(3-Hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]amino]-5-oxopentanoic acid β-D-Glucopyranosiduronic acid
EINECS	Contact for details

Quality Control

Our Alvimopan Acyl-β-D-Glucuronide is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to relevant industry standards to support our clients' regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.