Description

(R)-A-(Fmoc-Amino)-3-Methoxybenzeneacetic Acid CAS NO 1260614-82-1 is a high-purity, non-natural amino acid derivative featuring a chiral center and an Fmoc-protected amino group. This compound is a critical chiral building block for the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics, enabling the introduction of a methoxy-substituted aromatic side chain with defined stereochemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptide-based diagnostics, and advanced biomaterials.

Application

• Peptide Synthesis: As a key chiral intermediate in Fmoc-based solid-phase peptide synthesis (SPPS) for incorporating a (R)-configured, methoxybenzene-containing amino acid residue.
• Pharmaceutical Research: For the discovery and development of peptide-based drugs targeting GPCRs, enzymes, and protein-protein interactions where aromatic and chiral elements are crucial for bioactivity.
• Peptidomimetic Design: In the creation of metabolically stable peptide analogs and constrained structures for improved pharmacokinetic properties.
• Bioconjugation & Labeling: The carboxylic acid moiety allows for conjugation to other molecules, carriers, or fluorescent tags for diagnostic probe development.
• Chemical Biology Probes: Synthesis of activity-based probes or affinity tags to study enzyme function and protein localization.
• Material Science: Incorporation into synthetic polymers or hydrogels to impart bioactivity or specific chiral recognition properties.

Basic Information

Product Name	(R)-A-(Fmoc-Amino)-3-Methoxybenzeneacetic Acid
CAS No.	1260614-82-1
Molecular Formula	C24H21NO6
Molecular Weight	419.43 g/mol
Synonyms	(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(3-methoxyphenyl)acetic acid; (R)-Fmoc-3-methoxy-phenylglycine; (R)-N-Fmoc-3-methoxy-phenylglycine; (R)-2-(Fmoc-amino)-2-(3-methoxyphenyl)acetic acid; (R)-α-(Fmoc-amino)-3-methoxybenzeneacetic acid; (R)-3-Methoxy-Fmoc-phenylglycine; Fmoc-(R)-3-MeO-Phg-OH; (R)-N-α-Fmoc-3-methoxyphenylglycine
EINECS	Contact for details

Quality Control

Our (R)-A-(Fmoc-Amino)-3-Methoxybenzeneacetic Acid is manufactured under strict quality control protocols to ensure high chemical and chiral purity, essential for sensitive peptide synthesis. Each batch is analyzed via HPLC, NMR, and optical rotation to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.