Description

Fmoc-2,5-Dichloro-L-Phenylalanine is a protected, non-natural amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound matters for its role in constructing complex peptide sequences with enhanced stability and specific bioactivity, particularly in research targeting novel therapeutics. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and academic laboratories focused on developing peptide-based drugs, diagnostic agents, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for incorporating 2,5-dichlorophenylalanine residues into peptide chains, enabling the creation of peptides with modified properties.
• Pharmaceutical Research: For the development of novel therapeutic peptides, including antimicrobial peptides (AMPs) and hormone analogs, where halogenation can influence receptor binding and metabolic stability.
• Chemical Biology & Proteomics: Used to synthesize peptide probes and activity-based probes for studying enzyme function and protein-protein interactions.
• Material Science: Incorporation into peptidomimetics and bio-inspired polymers to create materials with specific self-assembly or functional characteristics.
• Agrochemical Research: Potential use in the synthesis of bioactive peptide derivatives for crop protection agents.

Basic Information

Product Name	Fmoc-2,5-Dichloro-L-Phenylalanine
CAS No.	1260614-80-9
Molecular Formula	C24H19Cl2NO4
Molecular Weight	456.32 g/mol
Synonyms	Fmoc-2,5-Dichloro-L-Phe-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2,5-dichloro-L-phenylalanine; Fmoc-Dichlorophenylalanine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-3-(2,5-dichlorophenyl)propanoic acid; N-Fmoc-2,5-dichloro-L-phenylalanine; Fmoc-L-2,5-DichloroPhe; Fmoc-2,5-diCl-L-Phe; 2,5-Dichloro-L-phenylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our Fmoc-2,5-Dichloro-L-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for peptide synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.