Description

(2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-4-[3-(Trifluoromethoxy)Phenyl]Butanoic Acid CAS NO 1260614-06-9 is a high-purity, non-natural amino acid derivative featuring a fluorenylmethoxycarbonyl (Fmoc) protecting group and a trifluoromethoxy-substituted phenyl side chain. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled assembly of complex peptides and peptidomimetics for advanced research. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on developing novel therapeutic peptides, diagnostic agents, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it serves as a key monomer for the sequential construction of custom peptide sequences.
• Pharmaceutical Research & Development: Used in the discovery and development of peptide-based drugs, where the trifluoromethoxy group can enhance metabolic stability and binding affinity.
• Peptidomimetic Design: Incorporation into synthetic peptide analogs to study structure-activity relationships (SAR) and improve pharmacological properties.
• Bioconjugation and Probe Development: Acts as a specialized component for creating labeled peptides or affinity tags used in biochemical assays and imaging.
• Combinatorial Chemistry Libraries: A valuable building block for generating diverse compound libraries for high-throughput screening in drug discovery.
• Academic Research: Employed in university and institutional labs for fundamental studies in organic chemistry, medicinal chemistry, and chemical biology.

Basic Information

Product Name	(2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-4-[3-(Trifluoromethoxy)Phenyl]Butanoic Acid
CAS No.	1260614-06-9
Molecular Formula	C26H22F3NO5
Molecular Weight	485.45 g/mol
Synonyms	Fmoc-3-(3-Trifluoromethoxyphenyl)-L-alanine; Fmoc-L-3-(3-Trifluoromethoxyphenyl)alanine; Fmoc-3-(3-(Trifluoromethoxy)phenyl)-L-alanine; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(3-(trifluoromethoxy)phenyl)butanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(3-trifluoromethoxyphenyl)-L-alanine; Fmoc-3-(3-CF3O-Phe)-OH; Fmoc-3-(3-Trifluoromethoxy-Phe)-OH; Fmoc-Tfm-Phe-OH
EINECS	Contact for details

Quality Control

Our (2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-4-[3-(Trifluoromethoxy)Phenyl]Butanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and comprehensive spectroscopic identification (NMR, MS). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports applications requiring high-purity, well-characterized building blocks for sensitive synthetic workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach ambient temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.