Description

(S)-A-(Fmoc-Amino)-3-Methoxybenzeneacetic Acid CAS NO 1260609-39-9 is a high-purity, non-natural amino acid derivative featuring a 9-fluorenylmethoxycarbonyl (Fmoc) protecting group on the amine and a methoxy-substituted aromatic side chain. This compound is a critical chiral building block designed for the solid-phase peptide synthesis (SPPS) of complex peptides and peptidomimetics, where precise stereochemistry and side-chain functionality are paramount. It is essential for researchers and manufacturers in pharmaceutical development, biotechnology, and advanced materials science who require reliable, high-quality intermediates for creating novel therapeutic candidates and bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected amino acid for the automated, sequential assembly of peptides, enabling the incorporation of a methoxybenzene moiety.
• Pharmaceutical Research & Development: Used as a chiral intermediate in the synthesis of peptide-based drug candidates, including GPCR-targeted therapies and enzyme inhibitors.
• Peptidomimetic Design: Facilitates the creation of non-natural peptide analogs with enhanced metabolic stability, bioavailability, and target selectivity.
• Combinatorial Chemistry Libraries: Serves as a valuable building block for generating diverse compound libraries for high-throughput screening in drug discovery.
• Bioconjugation and Probe Development: The aromatic side chain can be utilized for further chemical modification or as a reporter group in fluorescent or affinity probes.
• Academic Research: Employed in university and institutional labs for studying protein-protein interactions, signal transduction pathways, and structure-activity relationships (SAR).

Basic Information

Product Name	(S)-A-(Fmoc-Amino)-3-Methoxybenzeneacetic Acid
CAS No.	1260609-39-9
Molecular Formula	C24H21NO5
Molecular Weight	403.43 g/mol
Synonyms	(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(3-methoxyphenyl)acetic acid; Fmoc-3-methoxy-DL-phenylglycine; Fmoc-(3-MeO)Phg-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-methoxy-DL-phenylglycine; (S)-2-(Fmoc-amino)-2-(3-methoxyphenyl)acetic acid; Nα-Fmoc-3-methoxy-phenylglycine; Fmoc-3-MeO-Phg-OH; (S)-N-Fmoc-3-methoxyphenylglycine
EINECS	Contact for details

Quality Control

Our (S)-A-(Fmoc-Amino)-3-Methoxybenzeneacetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure compliance with exacting research and development standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); desiccants are recommended for long-term storage. Keep the container tightly sealed when not in use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.