Description

n-Fmoc-S-2-Chlorophenylglycine CAS NO 1260608-83-0 is a high-purity, non-natural amino acid derivative specifically engineered for advanced peptide synthesis. This compound is a critical building block in the production of complex peptide-based pharmaceuticals and research compounds, offering precise stereochemical control. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on developing novel therapeutic agents and bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of complex peptides, particularly those requiring the incorporation of sterically hindered or halogenated phenylglycine residues.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the development of Active Pharmaceutical Ingredients (APIs) for potential drugs targeting metabolic disorders, neurological conditions, and oncology.
• Peptidomimetic Research: Used to create peptide analogs with enhanced stability, bioavailability, and target specificity by introducing chlorophenyl modifications.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse compound libraries for high-throughput screening in drug discovery programs.
• Bioconjugation: Facilitates the site-specific labeling or functionalization of peptides and proteins for diagnostic and therapeutic applications.
• Academic & Industrial R&D: A fundamental reagent for investigating protein-protein interactions, enzyme mechanisms, and structure-activity relationships (SAR).

Basic Information

Product Name	n-Fmoc-S-2-Chlorophenylglycine
CAS No.	1260608-83-0
Molecular Formula	C23H18ClNO4
Molecular Weight	407.85 g/mol
Synonyms	Fmoc-2-Chloro-DL-phenylglycine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-chloro-DL-phenylglycine; Fmoc-2-Cl-Phg-OH; (RS)-N-Fmoc-2-chlorophenylglycine; 2-Chloro-N-[(9H-fluoren-9-ylmethoxy)carbonyl]phenylglycine; N-Fmoc-2-chloro-α-aminophenylacetic acid; Fmoc-(2-Cl)Phe-gly-OH
EINECS	Contact for details

Quality Control

Every batch of n-Fmoc-S-2-Chlorophenylglycine is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive peptide synthesis. Our products are supported by comprehensive Certificates of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to industry best practices and can provide material suitable for research and development under cGMP guidelines upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. Allow the container to reach room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (S-enantiomer)
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.