Description

3,5-Dichloro-n-Fmoc-L-Phenylalanine CAS NO 1260605-95-5 is a protected, non-natural amino acid derivative designed for solid-phase peptide synthesis (SPPS). This compound is critical for the controlled introduction of halogenated aromatic side chains into peptide sequences, enabling the development of peptides with enhanced stability, binding affinity, and specific biological activity. It is an essential building block for researchers and manufacturers in pharmaceutical R&D, particularly for creating therapeutic peptides, peptidomimetics, and chemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected amino acid for the automated synthesis of custom peptides containing halogenated phenylalanine residues.
• Pharmaceutical Intermediate: Used in the research and development of novel peptide-based therapeutics, including hormone analogs, enzyme inhibitors, and targeted drug conjugates.
• Peptidomimetic Design: Incorporates chlorine atoms to modulate the hydrophobicity, electronic properties, and metabolic stability of peptide backbones in drug discovery.
• Chemical Biology Probes: Serves as a building block for synthesizing labeled or modified peptides used in studying protein-protein interactions and cellular pathways.
• Agrochemical Research: Potential use in the development of bioactive peptides for crop protection and agricultural science applications.

Basic Information

Product Name	3,5-Dichloro-n-Fmoc-L-Phenylalanine
CAS No.	1260605-95-5
Molecular Formula	C24H19Cl2NO4
Molecular Weight	456.32 g/mol
Synonyms	Fmoc-3,5-dichloro-L-phenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3,5-dichloro-L-phenylalanine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-3-(3,5-dichlorophenyl)propanoic acid; Fmoc-Dichloro-Phe-OH; Fmoc-3,5-DiCl-Phe-OH; N-α-Fmoc-3,5-dichloro-L-phenylalanine; Fmoc-L-3,5-dichlorophenylalanine; 3,5-Dichloro-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine
EINECS	Contact for details

Quality Control

Our 3,5-Dichloro-n-Fmoc-L-Phenylalanine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via NMR and mass spectrometry. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research and cGMP-grade requirements for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.