Description

n-Fmoc-4-Methoxy-D-Homophenylalanine is a protected, non-natural amino acid derivative essential for advanced peptide synthesis. This compound is specifically engineered to introduce a homophenylalanine backbone with a methoxy substituent and D-configuration into peptide chains, enabling the creation of novel bioactive molecules with enhanced stability and targeted properties. It is a critical building block for pharmaceutical researchers and peptide chemists developing therapeutic peptides, peptidomimetics, and chemical biology probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc-strategy in automated and manual peptide assembly.
• Pharmaceutical Research & Development: Used in the synthesis of novel peptide-based drug candidates, including GLP-1 analogs, antimicrobial peptides, and hormone analogs.
• Peptidomimetic Design: Incorporates structural diversity to mimic natural peptides while improving metabolic stability and bioavailability.
• Chemical Biology & Proteomics: Serves as a tool for studying protein-protein interactions and enzyme mechanisms through site-specific incorporation.
• API Intermediate Manufacturing: Acts as a chiral building block in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs).
• Material Science: Potential use in creating functionalized biomaterials and peptide-based polymers.

Basic Information

Product Name	n-Fmoc-4-Methoxy-D-Homophenylalanine
CAS No.	1260601-38-4
Molecular Formula	C26H25NO6
Molecular Weight	447.48 g/mol
Synonyms	Fmoc-D-Hph(4-OMe)-OH; Fmoc-4-Methoxy-D-homophenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-methoxy-D-homophenylalanine; (2R)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-4-(4-methoxyphenyl)butanoic acid; D-4-Methoxyhomophenylalanine, N-Fmoc derivative; Fmoc-D-4-MeO-Hph-OH; N-α-Fmoc-4-methoxy-D-homophenylalanine
EINECS	Contact for details

Quality Control

Our n-Fmoc-4-Methoxy-D-Homophenylalanine is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for research and cGMP applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and MS for identity verification. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.