Description

(2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-4-(Pyridin-2-Yl)Butanoic Acid CAS NO 1260601-08-8 is a high-purity, non-natural amino acid derivative featuring a pyridyl side chain and an Fmoc-protected α-amino group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the precise incorporation of structurally complex amino acids into target sequences. It is essential for researchers and manufacturers in pharmaceutical development, particularly for creating novel peptide-based therapeutics, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental reagent for the automated synthesis of custom peptides.
• Pharmaceutical Research & Development: Used to synthesize peptide drug candidates, especially those targeting protein-protein interactions where the pyridyl moiety can enhance binding affinity.
• Bioconjugation and Probe Development: Serves as a precursor for creating fluorescently labeled or affinity-tagged peptides for diagnostic and imaging applications.
• Chemical Biology Studies: Incorporation into peptides to study enzyme-substrate interactions, receptor binding, and signal transduction pathways.
• Material Science: Potential use in creating peptide-based biomaterials and surface coatings where specific molecular recognition is required.
• Academic Research: A key reagent in university and institutional labs for exploring novel peptide structures and functions.

Basic Information

Item	Details
Product Name	(2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-4-(Pyridin-2-Yl)Butanoic Acid
CAS No.	1260601-08-8
Molecular Formula	C24H20N2O4
Molecular Weight	400.43 g/mol
Synonyms	Fmoc-(S)-2-amino-4-(2-pyridyl)butyric acid; Fmoc-4-(2-Pyridyl)-L-homoalanine; Fmoc-L-4-(2-Pyridyl)homoalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-(2-pyridinyl)-L-homoalanine; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-4-(2-pyridinyl)butanoic acid; Fmoc-Hph(2-Py)-OH; Fmoc-L-Hph(2-Pyridyl)-OH
EINECS	Contact for details

Quality Control

Our (2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-4-(Pyridin-2-Yl)Butanoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research and cGMP-grade material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccation and storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.