Description

n-Fmoc-3-(2-Biphenylyl)-L-Alanine/(S)-2-(((9H-Fluoren-9-Yl)Methoxy)Carbonylamino)-3-(Biphenyl-2-Yl)Propanoic Acid CAS NO 1260592-50-4 is a high-purity, non-natural amino acid derivative featuring an Fmoc-protected amine group and a biphenyl side chain. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the precise incorporation of a bulky, aromatic moiety to modulate peptide structure, stability, and receptor binding affinity. It is essential for researchers and manufacturers in pharmaceutical R&D, biotechnology, and advanced materials science who require reliable, high-quality intermediates for developing novel peptide-based therapeutics, diagnostics, and bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key protected amino acid monomer for the automated synthesis of complex peptides.
• Pharmaceutical Research & Development: Used to create peptide drug candidates with enhanced metabolic stability and target affinity by introducing the hydrophobic biphenyl group.
• Peptidomimetic Design: Integral for developing peptide analogs and mimetics where the biphenyl moiety mimics protein-protein interaction interfaces.
• Chemical Biology Probes: Employed in the synthesis of labeled or modified peptides for studying biological pathways and enzyme functions.
• Combinatorial Chemistry Libraries: A valuable component for generating diverse peptide libraries for high-throughput screening against therapeutic targets.
• Material Science: Potential use in creating functionalized surfaces or bio-conjugates due to its aromatic and reactive groups.

Basic Information

Product Name	n-Fmoc-3-(2-Biphenylyl)-L-Alanine/(S)-2-(((9H-Fluoren-9-Yl)Methoxy)Carbonylamino)-3-(Biphenyl-2-Yl)Propanoic Acid
CAS No.	1260592-50-4
Molecular Formula	C31H27NO4
Molecular Weight	477.55 g/mol
Synonyms	Fmoc-Bip(2)-Ala-OH; Fmoc-2-Biphenylalanine; Fmoc-3-(2-Biphenylyl)-L-alanine; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonylamino)-3-(biphenyl-2-yl)propanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(2-biphenylyl)-L-alanine; Fmoc-Bip(2)-OH; Fmoc-L-Bip(2)-OH; N-α-Fmoc-3-(2-biphenylyl)-L-alanine
EINECS	Contact for details

Quality Control

Our n-Fmoc-3-(2-Biphenylyl)-L-Alanine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and development applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and MS for identity verification. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific project requirements or internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and may require storage under an inert atmosphere for long-term preservation. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.