Description

(2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-4-(Pyridin-3-Yl)Butanoic Acid CAS NO 1260592-33-3 is a high-purity, non-natural amino acid derivative featuring a pyridin-3-yl side chain and an Fmoc-protected α-amino group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the precise incorporation of a heterocyclic aromatic moiety to modulate peptide bioactivity and physicochemical properties. It is essential for researchers and manufacturers in pharmaceutical development, particularly for creating novel peptide-based therapeutics, diagnostic agents, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental reagent for the automated, stepwise construction of custom peptide sequences.
• Pharmaceutical R&D: Used to synthesize peptide drug candidates where the pyridine ring contributes to hydrogen bonding, solubility, or target binding affinity.
• Bioconjugation: Serves as a precursor for creating peptide-based conjugates for drug delivery systems or diagnostic imaging agents.
• Chemical Biology Probes: Incorporated into peptides to study protein-protein interactions, enzyme mechanisms, or cellular signaling pathways.
• Material Science: Can be used to create functionalized surfaces or bio-inspired polymers with specific molecular recognition properties.

Basic Information

Product Name	(2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-4-(Pyridin-3-Yl)Butanoic Acid
CAS No.	1260592-33-3
Molecular Formula	C24H20N2O4
Molecular Weight	400.43 g/mol
Synonyms	Fmoc-3-Pyridylalanine; Fmoc-3-Pal-OH; N-α-Fmoc-3-(3-pyridyl)-L-alanine; Fmoc-L-3-pyridylalanine; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(pyridin-3-yl)propanoic acid; Fmoc-3-(3-Pyridyl)-L-alanine; N-α-9-Fluorenylmethoxycarbonyl-3-(3-pyridinyl)-L-alanine
EINECS	Contact for details

Quality Control

Our (2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-4-(Pyridin-3-Yl)Butanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for peptide synthesis and pharmaceutical research. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccation and under an inert atmosphere to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.