Description

(S)-Benzo[1,3]Dioxol-5-Yl-[(9H-Fluoren-9-Ylmethoxycarbonylamino)]-Acetic Acid CAS NO 1260591-11-4 is a sophisticated chiral building block and protected amino acid derivative, essential for advanced organic synthesis. Its core value lies in enabling the precise construction of complex peptide and small molecule structures with defined stereochemistry, which is critical for developing bioactive compounds. This high-purity intermediate is primarily needed by pharmaceutical R&D teams, contract research organizations (CROs), and fine chemical manufacturers focused on producing novel therapeutics, particularly in areas like neurology and oncology.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and anti-cancer drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected Fmoc-amino acid derivative for introducing specific, non-proteinogenic amino acid residues.
• Chemical Biology & Proteomics: Serves as a building block for creating peptide-based probes, inhibitors, and tools to study enzyme function and protein-protein interactions.
• Asymmetric Synthesis: Employed in the synthesis of complex natural products and chiral molecules where the (S)-configuration and the benzo[1,3]dioxole moiety are required.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring high stereochemical purity and reliable supply chain integrity.
• Academic Research: Utilized in university and institutional laboratories for methodological development in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	(S)-Benzo[1,3]Dioxol-5-Yl-[(9H-Fluoren-9-Ylmethoxycarbonylamino)]-Acetic Acid
CAS No.	1260591-11-4
Molecular Formula	C25H19NO6
Molecular Weight	429.42 g/mol
Synonyms	Fmoc-3,4-(Methylenedioxy)-L-phenylglycine; Fmoc-(S)-2-Amino-2-(benzo[d][1,3]dioxol-5-yl)acetic acid; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(benzo[d][1,3]dioxol-5-yl)acetic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3,4-methylenedioxy-L-phenylglycine; Fmoc-L-3,4-MDPG-OH; Fmoc-3,4-Methylenedioxy-L-phenylglycine; N-Fmoc-3,4-(methylenedioxy)-L-phenylglycine
EINECS	Contact for details

Quality Control

Our production of (S)-Benzo[1,3]Dioxol-5-Yl-[(9H-Fluoren-9-Ylmethoxycarbonylamino)]-Acetic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC to confirm enantiomeric excess (ee) and standard pharmacopeial identification tests. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.