Description

Fmoc-2-Chloro-L-Homophenylalanine CAS NO 1260590-75-7 is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis and pharmaceutical research. This compound is a critical building block for introducing the unique 2-chloro-homophenylalanine moiety into peptide chains, enabling the development of novel bioactive molecules with enhanced properties. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on peptide-based drug discovery and development.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/tert-butyl strategy, enabling the controlled incorporation of a chlorinated aromatic side chain.
• Peptidomimetic Drug Development: Used to create peptide analogs with improved metabolic stability, receptor selectivity, and bioavailability by introducing a halogenated hydrophobic residue.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of potential therapeutic peptides targeting GPCRs, enzymes, and other biological targets.
• Chemical Biology Research: Employed in the study of protein-protein interactions and enzyme mechanisms by acting as a site-specific probe or inhibitor component.
• Combinatorial Chemistry Libraries: Used to generate diverse peptide libraries for high-throughput screening in drug discovery campaigns.
• Agrochemical Research: Potential application in the design of novel bioactive peptides for crop protection.

Basic Information

Product Name	Fmoc-2-Chloro-L-Homophenylalanine
CAS No.	1260590-75-7
Molecular Formula	C25H22ClNO4
Molecular Weight	435.90 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-chloro-L-homophenylalanine; Fmoc-2-Cl-Hph-OH; Fmoc-2-chloro-homoPhe-OH; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-4-(2-chlorophenyl)butanoic acid; N-Fmoc-2-chloro-L-homophenylalanine; 2-Chloro-L-homophenylalanine, N-Fmoc derivative; Fmoc-2-chloro-DL-homophenylalanine (racemic mixture reference)
EINECS	Contact for details

Quality Control

Our Fmoc-2-Chloro-L-Homophenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification (NMR, MS). Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with research and cGMP guidelines for non-GMP starting materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.