Description

Fmoc-2,6-Dichloro-D-Phenylalanine CAS NO 1260590-53-1 is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis. This compound is a critical building block for the development of novel peptide-based pharmaceuticals and research tools, offering precise stereochemical control. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in solid-phase peptide synthesis (SPPS) for creating complex molecules with enhanced stability and bioactivity.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated, stepwise construction of complex peptides and proteins.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the research and development of new therapeutic peptides, including antimicrobial and anticancer agents.
• Peptidomimetic Design: Used to incorporate halogenated phenylalanine analogs into peptide chains to modulate pharmacokinetic properties like metabolic stability and membrane permeability.
• Bioconjugation and Labeling: The Fmoc protecting group allows for selective deprotection, enabling site-specific modifications and labeling of peptides.
• Chemical Biology Research: Employed in the study of protein-protein interactions and enzyme mechanisms by introducing non-natural amino acids into peptide sequences.
• API Development: Acts as a building block in the synthesis of Active Pharmaceutical Ingredients (APIs) for clinical trial materials.

Basic Information

Product Name	Fmoc-2,6-Dichloro-D-Phenylalanine
CAS No.	1260590-53-1
Molecular Formula	C24H19Cl2NO4
Molecular Weight	456.32 g/mol
Synonyms	Fmoc-D-2,6-Dichlorophenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2,6-dichloro-D-phenylalanine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2,6-dichlorophenyl)propanoic acid; Fmoc-2,6-diCl-D-Phe-OH; Fmoc-D-2,6-DiCl-Phe; N-Fmoc-2,6-dichloro-D-phenylalanine; 2,6-Dichloro-D-phenylalanine Fmoc derivative
EINECS	Contact for details

Quality Control

Our Fmoc-2,6-Dichloro-D-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.