Description

Paricalcitol 25-β-D-Glucuronide CAS NO 1260588-15-5 is a key glucuronidated metabolite of the active vitamin D analog, paricalcitol. This compound is of significant interest for pharmaceutical research and development, particularly in the study of drug metabolism and pharmacokinetics (DMPK). It is primarily utilized by research institutions and pharmaceutical companies engaged in the development and bioanalytical validation of paricalcitol-based therapies.

Application

• Pharmaceutical Reference Standard: Serves as a critical certified reference material (CRM) for the quantitative and qualitative analysis of paricalcitol metabolites in biological matrices.
• Drug Metabolism & Pharmacokinetics (DMPK) Studies: Essential for in vitro and in vivo studies to understand the metabolic pathways, clearance mechanisms, and bioavailability of paricalcitol.
• Bioanalytical Method Development: Used as a standard for developing and validating sensitive HPLC-MS/MS or LC-MS methods for therapeutic drug monitoring and clinical research.
• Impurity Profiling: Acts as a known impurity or degradation product standard to ensure the purity and safety of paricalcitol active pharmaceutical ingredient (API) and finished drug products.
• Preclinical and Clinical Research: Supports investigative studies on the efficacy and safety profile of paricalcitol in treating secondary hyperparathyroidism associated with chronic kidney disease.

Basic Information

Product Name	Paricalcitol 25-β-D-Glucuronide
CAS No.	1260588-15-5
Molecular Formula	C35H52O12
Molecular Weight	664.78 g/mol
Synonyms	(1R,3S)-5-[2-[(1R,3aS,7aR)-1-[(2R,3E,5S)-5,6-Dimethyl-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol; 19-Nor-1α,25-dihydroxyvitamin D2 25-β-D-Glucuronide; Paricalcitol Glucuronide; Zemplar Metabolite (Glucuronide)
EINECS	Contact for details

Quality Control

Our Paricalcitol 25-β-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC purity assay, identity confirmation (IR, MS), and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 5.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.