Description

(S)-tert-Butyl 2-(2-Cyanoacetyl)Piperidine-1-Carboxylate is a high-purity, chiral piperidine derivative that serves as a critical building block in advanced organic synthesis. Its value lies in its role as a versatile intermediate for constructing complex molecules with defined stereochemistry, which is essential for developing active pharmaceutical ingredients (APIs) and other fine chemicals. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries engaged in the development of novel therapeutic agents and high-value chemical entities.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Research: Used in the development of novel pesticides and herbicides where the specific stereochemistry can influence biological activity and environmental degradation profiles.
• Asymmetric Synthesis: Employed as a precursor for chiral ligands, catalysts, or auxiliaries used in stereoselective transformations to create enantiomerically pure compounds.
• Peptidomimetics & Bioactive Molecule Construction: The piperidine scaffold with the cyanoacetyl handle is valuable for designing and synthesizing peptide analogs and other bioactive molecules with improved metabolic stability.
• Chemical Biology Probes: Serves as a starting material for creating labeled compounds or probes used to study biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in custom synthesis projects and scale-up campaigns for clients.

Basic Information

Product Name	(S)-tert-Butyl 2-(2-Cyanoacetyl)Piperidine-1-Carboxylate
CAS No.	1260587-50-5
Molecular Formula	C13H20N2O3
Molecular Weight	252.31 g/mol
Synonyms	1-Boc-2-(2-cyanoacetyl)piperidine (S)-enantiomer; (S)-1-(tert-Butoxycarbonyl)-2-(2-cyanoacetyl)piperidine; (S)-N-Boc-2-(cyanomethylcarbonyl)piperidine; tert-Butyl (S)-2-(2-cyanoacetyl)piperidine-1-carboxylate; (S)-1-Boc-piperidine-2-(2-cyanoacetamide); (S)-2-(2-Cyanoacetyl)-1-(tert-butoxycarbonyl)piperidine; (S)-Boc-2-(cyanoacetyl)piperidine; (S)-tert-Butyl 2-(cyanomethylcarbonyl)piperidine-1-carboxylate
EINECS	Contact for details

Quality Control

Our (S)-tert-Butyl 2-(2-Cyanoacetyl)Piperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure enantiomeric purity, NMR and IR for structural confirmation, and standard purity assays. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability, consistency, and reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere (e.g., nitrogen or argon) to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.