Description

(S)-4-Fluorohomophenylalanine is a high-purity, non-natural amino acid derivative featuring a fluorinated aromatic side chain. This compound is a critical chiral building block in modern pharmaceutical research and development, enabling the synthesis of novel bioactive molecules with enhanced metabolic stability and binding affinity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery of peptide-based therapeutics, enzyme inhibitors, and targeted drug delivery systems.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and CNS drug discovery.
• Peptidomimetics & PROTACs: Used to incorporate fluorinated phenylalanine analogs into peptide backbones to improve proteolytic stability and membrane permeability for advanced therapeutic modalities.
• Enzyme Inhibitor Development: Serves as a core structure for designing potent and selective inhibitors of amino acid-processing enzymes.
• Bioconjugation & Probe Synthesis: Employed in the creation of fluorescent or affinity probes for biochemical assays and target identification studies.
• Material Science Research: Investigated for the development of novel fluorinated polymers and biomaterials with unique surface properties.

Basic Information

Product Name	(S)-4-Fluorohomophenylalanine
CAS No.	1260587-28-7
Molecular Formula	C₁₀H₁₂FNO₂
Molecular Weight	197.21 g/mol
Synonyms	(S)-2-Amino-4-(4-fluorophenyl)butanoic acid; (S)-4-(4-Fluorophenyl)homophenylalanine; H-4-F-hPhe-OH; Fmoc-4-F-hPhe-OH; 4-Fluoro-DL-homophenylalanine (racemic mixture); 4-Fluorohomophenylalanine; 4-(4-Fluorophenyl)-L-homoalanine
EINECS	Contact for details

Quality Control

Our (S)-4-Fluorohomophenylalanine is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure it meets the high standards required for pharmaceutical R&D. A Certificate of Analysis (COA) detailing purity, chiral excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider desiccant in the storage environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.