Description

n-Boc-2-Chloro-D-Homophenylalanine is a protected, non-natural amino acid derivative of significant value in advanced organic synthesis. This compound serves as a crucial chiral building block for the construction of complex peptide mimetics and bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, including protease inhibitors and other peptidomimetic drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other peptide-based therapeutics.
• Peptidomimetic Research: Used to incorporate modified phenylalanine analogs into peptide chains to enhance stability, bioavailability, and biological activity.
• Chemical Biology Probes: Employed in the synthesis of labeled or tagged peptides for studying enzyme mechanisms and protein-protein interactions.
• Asymmetric Synthesis: Serves as a valuable starting material or intermediate in stereoselective synthesis due to its defined D-configuration and protected amine functionality.
• Custom Peptide Synthesis: Utilized by CROs and CDMOs for the production of specialized, non-standard peptides for client research programs.

Basic Information

Product Name	n-Boc-2-Chloro-D-Homophenylalanine
CAS No.	1260587-00-5
Molecular Formula	C15H20ClNO4
Molecular Weight	313.78 g/mol
Synonyms	(R)-2-((tert-Butoxycarbonyl)amino)-3-(4-chlorophenyl)butanoic acid; D-2-Chloro-homophenylalanine N-Boc derivative; Boc-2-Cl-D-hPhe-OH; (R)-3-(4-Chlorophenyl)-2-((tert-butoxycarbonyl)amino)butanoic acid; N-(tert-Butoxycarbonyl)-2-chloro-D-homophenylalanine; BOC-D-2-Chloro-homophe; 1260587-00-5
EINECS	Contact for details

Quality Control

Our n-Boc-2-Chloro-D-Homophenylalanine is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR/IR for structural confirmation, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to prevent degradation. Keep away from strong acids and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.