Description

17β-Estradiol-D3 3-β-D-Glucuronide is a high-purity, deuterium-labeled internal standard critical for ensuring analytical accuracy in quantitative bioanalysis. This compound is essential for researchers and laboratories requiring precise and reliable measurement of estradiol metabolites in complex biological matrices. It is primarily used by pharmaceutical R&D, clinical diagnostics, and contract research organizations (CROs) specializing in hormone analysis, pharmacokinetic studies, and method development for LC-MS/MS.

Application

• LC-MS/MS Internal Standard: For the precise quantification of endogenous 17β-estradiol and its glucuronide metabolites in biological fluids (plasma, serum, urine).
• Clinical Research & Diagnostics: Used in developing and validating assays for hormone level monitoring, endocrine disorder studies, and therapeutic drug monitoring.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Essential for tracking drug metabolism and disposition of estrogen-based therapeutics.
• Doping Control Analysis: Employed in sports anti-doping laboratories for the sensitive detection of synthetic estrogen abuse.
• Environmental & Food Safety Testing: Applied in trace analysis of estrogenic compounds in environmental samples and food products.
• Biomarker Discovery & Validation: Serves as a critical reference standard in proteomic and metabolomic research for hormone-related pathways.

Basic Information

Product Name	17β-Estradiol-D3 3-β-D-Glucuronide
CAS No.	1260231-06-8
Molecular Formula	C24H29D3O8
Molecular Weight	451.5 g/mol (approx.)
Synonyms	Estradiol-17β-D3 3-Glucuronide; [2,4,16,16,17-2H5]-Estradiol 3-Glucuronide (common notation); Deuterated Estradiol Glucuronide; 17β-Estradiol-2,4,16,16,17-d5 3-β-D-Glucuronide; E2-3G-D3; Internal Standard for Estradiol Glucuronide; (17β)-3-(β-D-Glucopyranuronosyloxy)-estra-1,3,5(10)-triene-2,4,16,16,17-d5-17-ol
EINECS	Contact for details

Quality Control

Every batch of 17β-Estradiol-D3 3-β-D-Glucuronide is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, with comprehensive testing via NMR, HPLC, and MS to confirm identity, potency, and deuterium enrichment. Certificates of Analysis (COA) detailing lot-specific results are provided and traceable to certified reference materials, supporting compliance with GLP and ISO 17025 standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.