Description

Bromoacetamido-Peg4-Nhs Ester is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring a reactive NHS ester and a bromoacetamide group. This compound is specifically engineered for creating stable, covalent conjugations between amine-containing molecules and thiol groups, offering superior control in bioconjugation strategies. It is an essential reagent for researchers and manufacturers in biopharmaceutical development, diagnostic assay production, and advanced materials science who require precise and reliable linker chemistry.

Application

• Antibody-Drug Conjugate (ADC) Linker: A key building block for constructing cleavable or non-cleavable linkers that connect cytotoxic payloads to monoclonal antibodies.
• Protein and Peptide Modification: For site-specific labeling, immobilization, or PEGylation of proteins via amine residues, with the bromoacetamide group available for subsequent thiol coupling.
• Surface Functionalization: Used to modify nanoparticles, biosensor chips, or chromatography resins with amine-reactive groups for subsequent biomolecule attachment.
• Crosslinking Agent: Enables the formation of hydrogels or polymer networks by reacting with both amine and thiol functional groups on different macromolecules.
• Diagnostic Reagent Synthesis: Employed in the development of enzyme conjugates or fluorescent probes for immunoassays and histochemistry.
• Biomaterial Engineering: Facilitates the creation of bioactive scaffolds with controlled ligand presentation for tissue engineering applications.

Basic Information

Product Name	Bromoacetamido-Peg4-Nhs Ester
CAS No.	1260139-70-5
Molecular Formula	C21H35BrN2O10
Molecular Weight	555.42 g/mol
Synonyms	NHS-PEG4-Bromoacetamide; Bromoacetamido-PEG4-NHS Ester; 2,5-Dioxopyrrolidin-1-yl 3-[2-[2-[2-[2-(2-bromoacetamido)ethoxy]ethoxy]ethoxy]ethoxy]propanoate; Bromoacetyl-PEG4-NHS ester; α-Bromoacetamido-ω-NHS-PEG4; BAPA-PEG4-NHS; N-(Bromoacetyl)-PEG4-NHS; Bromoacetamide-PEG4-NHS
EINECS	Contact for details

Quality Control

Our Bromoacetamido-Peg4-Nhs Ester is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to industry best practices, and specifications can be aligned with customer requirements for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.