Description

T-Boc-n-Amido-Peg1-Nhs Ester is a heterobifunctional crosslinking reagent featuring a protected amine group and an amine-reactive N-hydroxysuccinimide (NHS) ester. This compound is specifically engineered for the controlled and efficient conjugation of biomolecules, such as peptides and proteins, to other functional entities. It is an essential building block for researchers and manufacturers in the fields of bioconjugation, proteomics, and the development of antibody-drug conjugates (ADCs) and other advanced therapeutic modalities.

Application

• Bioconjugation Linker: Used to covalently attach peptides, proteins, or antibodies to surfaces, polymers, nanoparticles, or other biomolecules via amine groups.
• Antibody-Drug Conjugate (ADC) Synthesis: Serves as a key intermediate for constructing cleavable or non-cleavable linkers between monoclonal antibodies and cytotoxic payloads.
• Proteomics Research: Facilitates the labeling and cross-linking of proteins for mass spectrometry analysis, protein interaction studies, and structural biology.
• Polymer Functionalization: Enables the introduction of protected amine functionalities onto PEG (polyethylene glycol) or other polymer backbones for subsequent modification.
• Diagnostic Reagent Development: Employed in the creation of enzyme-linked immunosorbent assay (ELISA) components, fluorescent probes, and other diagnostic tools.
• Solid-Phase Peptide Synthesis (SPPS): Acts as a handle for the temporary protection of amines during the synthesis of complex peptide sequences.
• Material Science: Used to bio-functionalize materials for biomedical applications, such as tissue engineering scaffolds and biosensors.

Basic Information

Product Name	T-Boc-n-Amido-Peg1-Nhs Ester
CAS No.	1260092-55-4
Molecular Formula	C17H28N2O7
Molecular Weight	372.42 g/mol
Synonyms	1-Boc-3,6-dioxa-8-azaoctanoic acid N-succinimidyl ester; 2,5-Dioxopyrrolidin-1-yl 1-[(1,1-dimethylethoxy)carbonyl]-3,6-dioxa-8-azaoctanoate; Boc-N-amido-PEG1-NHS ester; tert-Butyl (2-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy)ethyl)carbamate; Boc-NH-PEG1-NHS; N-(tert-Butoxycarbonyl)-3,6-dioxa-8-azaoctanoic acid N-succinimidyl ester; Boc-8-amino-3,6-dioxaoctanoic acid NHS ester
EINECS	Contact for details

Quality Control

Our T-Boc-n-Amido-Peg1-Nhs Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your research and development quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.