Description

5-Chloro-2-Fluoro-Dl-Phenylalanine is a fluorinated and chlorinated derivative of the essential amino acid phenylalanine, serving as a versatile non-natural amino acid building block. This compound matters for its role in modulating the physicochemical and biological properties of peptides and small molecules, making it a critical intermediate in advanced research and development. It is primarily needed by pharmaceutical researchers and agrochemical scientists for applications in drug discovery, proteomics, and the synthesis of novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in oncology and CNS drug candidates.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate halogenated amino acids, altering peptide stability, lipophilicity, and receptor binding affinity.
• Proteomics & Biochemical Research: Serves as a tool compound for studying enzyme mechanisms, metabolic pathways, and protein structure-function relationships.
• Agrochemical Development: Acts as a building block for synthesizing novel herbicides, pesticides, and plant growth regulators with enhanced efficacy.
• Material Science: Potential monomer for creating specialized polymers and coatings with unique properties derived from its halogenated aromatic ring.
• Diagnostic Agent Precursor: Utilized in the synthesis of precursors for positron emission tomography (PET) tracers and other imaging agents.

Basic Information

Product Name	5-Chloro-2-Fluoro-Dl-Phenylalanine
CAS No.	1259966-96-5
Molecular Formula	C9H9ClFNO2
Molecular Weight	217.62 g/mol
Synonyms	DL-5-Chloro-2-fluorophenylalanine; (RS)-2-Amino-3-(5-chloro-2-fluorophenyl)propanoic acid; 5-Chloro-2-fluoro-DL-α-aminohydrocinnamic acid; 2-Fluoro-5-chloro-DL-phenylalanine; NSC 87680; Fmoc-5-Chloro-2-fluoro-DL-Phenylalanine (precursor); 5-Cl-2-F-DL-Phe
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-Fluoro-Dl-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis, to ensure compliance with research and development standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	DL-Racemate
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.