Description

2-Chloro-5-Fluoro-Dl-Phenylalanine is a halogenated, non-natural amino acid derivative that serves as a critical chiral building block in advanced organic synthesis. Its value lies in providing a versatile scaffold for introducing specific halogenated aromatic motifs into target molecules, enabling precise modulation of their physicochemical and biological properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, especially in medicinal chemistry programs targeting CNS disorders and metabolic diseases.
• Peptide Modification: Used to incorporate halogenated phenylalanine analogs into synthetic peptides to enhance stability, bioavailability, and receptor binding affinity.
• Agrochemical Synthesis: Serves as a precursor in the design of novel herbicides and pesticides, where the chloro-fluoro substitution pattern can influence activity and environmental persistence.
• Chemical Biology Probe Development: Employed in the synthesis of labeled compounds and molecular probes for studying enzyme mechanisms and protein-protein interactions.
• Material Science Research: Acts as a monomer or functional additive in the development of specialized polymers and advanced materials with tailored properties.

Basic Information

Product Name	2-Chloro-5-Fluoro-Dl-Phenylalanine
CAS No.	1259958-87-6
Molecular Formula	C9H9ClFNO2
Molecular Weight	217.62 g/mol
Synonyms	DL-2-Chloro-5-fluorophenylalanine; (RS)-2-Amino-3-(2-chloro-5-fluorophenyl)propanoic acid; 2-Chloro-5-fluoro-DL-α-phenylalanine; (±)-2-Chloro-5-fluorophenylalanine; 3-(2-Chloro-5-fluorophenyl)-DL-alanine; 2-Chloro-5-fluoro-DL-homophenylalanine; 2-Cl-5-F-DL-Phe
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for all our fine chemical intermediates. Production of 2-Chloro-5-Fluoro-Dl-Phenylalanine adheres to current Good Manufacturing Practices (cGMP) where applicable, ensuring batch-to-batch consistency and reliability. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, generated using validated analytical methods including HPLC, NMR, and MS. Our quality system is designed to meet the exacting standards of pharmaceutical and R&D customers worldwide.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.