Description

(2-Ethoxy-5-Fluoropyridin-4-Yl)Boronic Acid is a high-purity boronic acid derivative and a key synthetic building block in modern organic chemistry. Its primary value lies in its role as a versatile coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active pharmaceutical ingredients (APIs) and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, especially those containing fluorinated pyridine scaffolds for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific fluorinated heterocyclic structures.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic light-emitting diodes (OLEDs).
• Suzuki-Miyaura Cross-Coupling: The principal application is as a boronic acid reagent for palladium-catalyzed cross-coupling with aryl or vinyl halides to form carbon-carbon bonds.
• Chemical Biology & Probe Development: Utilized in the design and synthesis of molecular probes and inhibitors for studying biological pathways and enzyme functions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the custom synthesis of complex molecules on a commercial scale.

Basic Information

Product Name	(2-Ethoxy-5-Fluoropyridin-4-Yl)Boronic Acid
CAS No.	1259370-15-4
Molecular Formula	C7H9BFNO3
Molecular Weight	184.96 g/mol
Synonyms	2-Ethoxy-5-fluoropyridine-4-boronic acid; 4-Borono-2-ethoxy-5-fluoropyridine; (2-Ethoxy-5-fluoro-4-pyridinyl)boronic acid; 5-Fluoro-2-ethoxypyridine-4-boronic acid; 4-Pyridineboronic acid, 2-ethoxy-5-fluoro-; B-(2-Ethoxy-5-fluoropyridin-4-yl)boronic acid
EINECS	Contact for details

Quality Control

Our (2-Ethoxy-5-Fluoropyridin-4-Yl)Boronic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.