Description

1-Piperazinecarboxylic Acid, 2-Ethynyl-, 1,1-Dimethylethyl Ester is a high-value, protected piperazine derivative featuring a reactive ethynyl group, making it a versatile building block for advanced organic synthesis. This compound is critical for research and development in medicinal chemistry, where it serves as a key intermediate for constructing complex molecular architectures. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs) and other specialty chemicals.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Peptidomimetics & Bioactive Molecule Synthesis: Used to incorporate constrained piperazine scaffolds and alkyne functionalities into peptides and other bioactive compounds for structure-activity relationship (SAR) studies.
• Click Chemistry Reagent: The terminal alkyne group enables its use in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions for bioconjugation and polymer chemistry.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Agrochemical Research: Employed in the discovery and development of new crop protection agents and pesticides.
• Material Science: Used in the research of advanced polymers and functional materials with tailored properties.

Basic Information

Product Name	1-Piperazinecarboxylic Acid, 2-Ethynyl-, 1,1-Dimethylethyl Ester
CAS No.	1259014-64-6
Molecular Formula	C11H18N2O2
Molecular Weight	210.27 g/mol
Synonyms	tert-Butyl 2-ethynylpiperazine-1-carboxylate; 2-Ethynyl-1-Boc-piperazine; 1-Boc-2-ethynylpiperazine; N-Boc-2-ethynylpiperazine; 2-Ethynylpiperazine-1-carboxylic acid tert-butyl ester; Boc-2-ethynylpiperazine; (2-Ethynyl-piperazin-1-yl)-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-2-ethynylpiperazine
EINECS	Contact for details

Quality Control

Our 1-Piperazinecarboxylic Acid, 2-Ethynyl-, 1,1-Dimethylethyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, identity, and impurity profiles. Our quality management system is designed to meet the stringent requirements of our global pharmaceutical and fine chemical clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.