Description

(+/-)-cis-2-(Trifluoromethyl)Cyclopropanecarboxylic Acid CAS NO 1258652-18-4 is a high-value, fluorinated cyclopropane building block characterized by its unique strained-ring structure and trifluoromethyl group. This compound matters for its role in introducing conformational rigidity and lipophilicity into target molecules, which is critical for modulating biological activity and physicochemical properties. It is primarily needed by pharmaceutical and agrochemical research organizations for the synthesis of advanced intermediates, novel active ingredients, and for use in medicinal chemistry programs exploring structure-activity relationships.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and CNS-targeted therapies.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the CF3-cyclopropyl moiety enhances metabolic stability and bioavailability.
• Medicinal Chemistry & Drug Discovery: Serves as a privileged scaffold in fragment-based drug design and lead optimization to improve potency and selectivity.
• Material Science Research: Investigated as a monomer or additive for creating specialty polymers with unique surface properties and chemical resistance.
• Ligand and Catalyst Development: Employed in the synthesis of chiral ligands and organocatalysts for asymmetric synthesis applications.
• Fluorine Chemistry Research: A valuable compound for studying the effects of fluorinated cyclopropanes on molecular conformation and reactivity.

Basic Information

Product Name	(+/-)-cis-2-(Trifluoromethyl)Cyclopropanecarboxylic Acid
CAS No.	1258652-18-4
Molecular Formula	C5H5F3O2
Molecular Weight	154.09 g/mol
Synonyms	cis-2-(Trifluoromethyl)cyclopropanecarboxylic acid (racemic); (±)-cis-2-(Trifluoromethyl)cyclopropanecarboxylic acid; rac-cis-2-(Trifluoromethyl)cyclopropanecarboxylic acid; 2-(Trifluoromethyl)cyclopropanecarboxylic acid, cis- (racemic); 1,2-cis-2-(Trifluoromethyl)cyclopropanecarboxylic acid; Cyclopropanecarboxylic acid, 2-(trifluoromethyl)-, cis- (racemic mixture); Contact for details on additional trade names or identifiers.
EINECS	Contact for details

Quality Control

Our production of (+/-)-cis-2-(Trifluoromethyl)Cyclopropanecarboxylic Acid adheres to stringent quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications and test results are provided and available upon request. We support compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	Racemic mixture (50:50)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.