Description

1,1'-Biphenyl-2,2'-Diylbis((1S)-1-Phenylethyl)Phosphoramidite is a chiral phosphoramidite ligand, a critical class of organophosphorus compounds used in asymmetric synthesis. Its value lies in its ability to act as a highly effective ligand for transition metal catalysts, enabling the production of enantiomerically pure compounds with high selectivity and yield. This product is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control in catalytic reactions such as hydrogenation and cross-coupling.

Application

• Asymmetric Catalysis: As a key ligand for rhodium, iridium, and palladium complexes in enantioselective hydrogenation and other C-C bond-forming reactions.
• Pharmaceutical Intermediate Synthesis: For the production of chiral active pharmaceutical ingredients (APIs) where specific stereochemistry is required for biological activity.
• Agrochemical Manufacturing: In the synthesis of enantiomerically pure herbicides, fungicides, and insecticides to enhance efficacy and reduce environmental impact.
• Fine Chemical Production: Used in the manufacture of specialty chemicals, flavors, and fragrances that demand high enantiomeric purity.
• Academic & Industrial R&D: As a versatile building block and ligand in method development and discovery chemistry for novel synthetic pathways.
• Catalyst Library Development: For creating diverse catalyst systems screened for activity and selectivity in new asymmetric transformations.

Basic Information

Product Name	1,1'-Biphenyl-2,2'-Diylbis((1S)-1-Phenylethyl)Phosphoramidite
CAS No.	1258223-41-4
Molecular Formula	C40H38NO2P
Molecular Weight	595.71 g/mol
Synonyms	(S,S)-1,1'-Biphenyl-2,2'-diylbis(1-phenylethyl)phosphoramidite; (S,S)-BIPHEP-Phosphoramidite; (S,S)-2,2'-Bis(α-(N-pyrrolidinyl)benzyl)-1,1'-biphenyl; (S,S)-Bis((1-phenylethyl)amino)([1,1'-biphenyl]-2,2'-diyl)phosphine; Chiral Biphenyl Phosphoramidite Ligand; (S,S)-BIPHEP-PA; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of 1,1'-Biphenyl-2,2'-Diylbis((1S)-1-Phenylethyl)Phosphoramidite adheres to stringent quality protocols to ensure batch-to-batch consistency and high chemical purity, critical for reproducible catalytic performance. Each lot is fully characterized and undergoes rigorous analytical testing. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and identity is provided with every shipment, supporting compliance with cGMP and ISO 9001 standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Due to its moisture-sensitive and easily oxidized nature, this product must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended long-term storage temperature is 2-8°C. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.