Description

3-(Difluoromethyl)Azetidine is a versatile and high-value azetidine building block, distinguished by its difluoromethyl substituent. This functional group is critical for modulating the physicochemical and metabolic properties of target molecules in advanced synthesis. It serves as a key intermediate for pharmaceutical and agrochemical research, particularly in the development of novel active ingredients. Its unique structure makes it essential for medicinal chemists and process development scientists seeking to incorporate fluorine motifs.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel Active Pharmaceutical Ingredients (APIs), especially in kinase inhibitors and central nervous system (CNS) targeted drugs.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides and fungicides, where the difluoromethyl group can enhance bioavailability and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of advanced polymers and functional materials that require fluorine-containing heterocycles for specific electronic or surface properties.
• Chemical Biology Probes: Utilized to create tagged molecules and probes for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	3-(Difluoromethyl)Azetidine
CAS No.	1258067-20-7
Molecular Formula	C4H7F2N
Molecular Weight	107.10 g/mol
Synonyms	3-(Difluoromethyl)azetidine; Azetidine, 3-(difluoromethyl)-; 3-Difluoromethylazetidine; 1-Azetidine, 3-(difluoromethyl)-; 1258067-20-7; 3-(Difluoromethyl)-azetidine; 3-Difluoromethyl-azetidine
EINECS	Contact for details

Quality Control

Our 3-(Difluoromethyl)Azetidine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support our clients' regulatory needs with documentation suitable for research and development filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.