Description

Ethyl (2R,3S)-2-(4-((tert-Butoxycarbonyl)Amino)Phenyl)Piperidine-3-Carboxylate is a high-purity, stereochemically defined chiral building block of significant importance in advanced pharmaceutical synthesis. Its core value lies in providing a protected, enantiomerically pure piperidine scaffold essential for constructing complex drug candidates with precise three-dimensional architecture. This compound is critically needed by research and development teams in the pharmaceutical and biotechnology sectors, particularly for the development of targeted therapies in areas such as oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel Active Pharmaceutical Ingredients (APIs).
• Drug Discovery & Medicinal Chemistry: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Protease Inhibitor Development: Serves as a core structural motif in the design of inhibitors targeting specific enzymatic pathways.
• Peptidomimetic Research: Employed to create non-peptide compounds that mimic the structure and function of peptides.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in stereoselective catalytic reactions.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting outsourced pharmaceutical development.

Basic Information

Product Name	Ethyl (2R,3S)-2-(4-((tert-Butoxycarbonyl)Amino)Phenyl)Piperidine-3-Carboxylate
CAS No.	1257871-36-5
Molecular Formula	C19H28N2O4
Molecular Weight	348.44 g/mol
Synonyms	Boc-Pip(4-NH-Boc)-OEt; (2R,3S)-Ethyl 2-[4-[(tert-butoxycarbonyl)amino]phenyl]piperidine-3-carboxylate; 1-Boc-4-(4-Boc-aminophenyl)-3-ethoxycarbonylpiperidine; tert-Butyl N-[4-[(2R,3S)-3-(ethoxycarbonyl)piperidin-2-yl]phenyl]carbamate; Ethyl (2R,3S)-2-(4-(Boc-amino)phenyl)piperidine-3-carboxylate; 1257871-36-5; UNII-Contact for details
EINECS	Contact for details

Quality Control

Our Ethyl (2R,3S)-2-(4-((tert-Butoxycarbonyl)Amino)Phenyl)Piperidine-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure compliance with stringent pharmaceutical-grade standards. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive; desiccants are recommended for long-term storage. Keep away from strong acids and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.