Description

3-Bromo-5-Fluorophenylboronic Acid Mida Ester is a high-value, protected boronic acid derivative designed for advanced synthetic applications. This compound is engineered to provide superior stability and handling characteristics compared to its free boronic acid counterpart, making it a critical reagent in modern cross-coupling methodologies. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides requiring specific halogenated biphenyl structures.
• Material Science Research: Employed in the creation of organic electronic materials, such as OLEDs and semiconductors, where precise molecular conjugation is essential.
• Chemical Biology & Proteomics: Serves as a stable handle for bioconjugation and the development of activity-based probes and inhibitors.
• Academic & Industrial R&D: A versatile reagent for methodological development in organic synthesis and catalysis studies.
• Scale-up Process Chemistry: The Mida ester protection offers improved shelf-life and purification profiles, facilitating robust and reproducible manufacturing processes.

Basic Information

Product Name	3-Bromo-5-Fluorophenylboronic Acid Mida Ester
CAS No.	1257650-61-5
Molecular Formula	C₁₀H₉BBrFNO₂
Molecular Weight	300.90 g/mol
Synonyms	N-Methyliminodiacetic Acid (MIDA) Boronate Ester of 3-Bromo-5-Fluorophenylboronic Acid; (3-Bromo-5-fluorophenyl)-1,3,2-dioxaborolan-2-yl)-N-methylacetamide; 3-Bromo-5-fluorophenyl-MIDA-boronate; 3-Bromo-5-fluoro-MIDA-phenylboronate; B-(3-Bromo-5-fluorophenyl)-N-methyliminodiacetic acid boronate ester; 3-Br-5-F-PhB(MIDA); 1257650-61-5
EINECS	Contact for details

Quality Control

Every batch of 3-Bromo-5-Fluorophenylboronic Acid Mida Ester is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. We provide full traceability and Certificates of Analysis (COA) detailing purity, identity, and impurity profiles, ensuring compliance with research and development standards. Specifications can be tailored to meet specific project requirements, including custom purity grades for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.