Description

Boceprevir-D9 CAS NO 1256751-11-7 is a high-purity, deuterium-labeled analog of the antiviral drug Boceprevir, serving as a critical internal standard for precise quantitative analysis. This stable isotope-labeled compound is essential for ensuring accuracy and reliability in bioanalytical research, particularly in pharmacokinetic and metabolism studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical chemists requiring definitive standards for LC-MS/MS and other mass spectrometry applications.

Application

• Internal Standard for Mass Spectrometry: Used as a deuterated internal standard in LC-MS/MS and GC-MS methods for the accurate quantification of Boceprevir in biological matrices (plasma, serum, tissues).
• Drug Metabolism and Pharmacokinetics (DMPK): Critical for studying the absorption, distribution, metabolism, and excretion (ADME) profiles of Boceprevir in preclinical and clinical research.
• Bioanalytical Method Development and Validation: Enables the development of robust, sensitive, and specific analytical assays in compliance with FDA and ICH guidelines.
• Pharmaceutical Quality Control: Supports impurity profiling and assay verification of Boceprevir in active pharmaceutical ingredient (API) and finished drug product analysis.
• Clinical Research: Facilitates therapeutic drug monitoring and bioavailability/bioequivalence studies for hepatitis C virus (HCV) treatments.
• Metabolite Identification: Aids in the structural elucidation and quantification of Boceprevir metabolites using high-resolution mass spectrometry.

Basic Information

Product Name	Boceprevir-D9
CAS No.	1256751-11-7
Molecular Formula	C₂₇H₄₆D₉N₅O₅
Molecular Weight	Approx. 525.8 g/mol
Synonyms	(1R,2S,5S)-N-[(1S)-3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[(2S)-2-[[(1,1-Dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2-carboxamide-D9; Boceprevir-d9; Deuterated Boceprevir; SCH 503034-d9; Boceprevir (D9, 98%); Boceprevir Internal Standard D9
EINECS	Contact for details

Quality Control

Our Boceprevir-D9 is manufactured under strict quality management systems to ensure the highest standards of isotopic and chemical purity. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results from advanced analytical techniques including NMR, HPLC, and MS. We ensure compliance with relevant standards for research-grade materials, providing traceability and batch-to-batch consistency critical for regulatory submissions and long-term studies.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (Deuteration Degree)	≥98.0 atom % D
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.