Description

(R)-tert-Butyl 1-(Oxetan-3-Yl)Pyrrolidin-3-Ylcarbamate is a high-purity chiral building block and advanced pharmaceutical intermediate. This compound is of significant value for the synthesis of complex bioactive molecules, particularly in the development of new therapeutic agents. It is primarily needed by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the production of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, especially in central nervous system (CNS) and antiviral therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its rigid oxetane and pyrrolidine motifs.
• Process Chemistry & Scale-up: Serves as a critical starting material or intermediate in the development of scalable, GMP-compliant synthetic routes for API manufacturing.
• Asymmetric Synthesis: Utilized as a building block to introduce stereochemical complexity in the synthesis of enantiomerically pure compounds.
• Proteolysis Targeting Chimera (PROTAC) & Molecular Glue Development: A potential component in the construction of bifunctional molecules for targeted protein degradation.
• Chemical Biology & Probe Development: Can be incorporated into chemical probes for studying biological pathways and target engagement.

Basic Information

Product Name	(R)-tert-Butyl 1-(Oxetan-3-Yl)Pyrrolidin-3-Ylcarbamate
CAS No.	1256667-55-6
Molecular Formula	C12H22N2O3
Molecular Weight	242.32 g/mol
Synonyms	(R)-tert-Butyl (1-(oxetan-3-yl)pyrrolidin-3-yl)carbamate; tert-Butyl N-[(3R)-1-(oxetan-3-yl)pyrrolidin-3-yl]carbamate; (R)-1-(Oxetan-3-yl)pyrrolidin-3-amine, N-Boc protected; Boc-(R)-1-(Oxetan-3-yl)-3-aminopyrrolidine; (R)-3-((tert-Butoxycarbonyl)amino)-1-(oxetan-3-yl)pyrrolidine; (S)-Enantiomer of tert-butyl 1-(oxetan-3-yl)pyrrolidin-3-ylcarbamate (Related); Oxetane-pyrrolidine carbamate building block
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl 1-(Oxetan-3-Yl)Pyrrolidin-3-Ylcarbamate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity, correct stereochemistry, and consistency. Certificates of Analysis (COA) are provided, detailing results for assay, enantiomeric excess, and impurity profiles via HPLC, GC, and NMR. We support development and commercial projects requiring compliance with cGMP and ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.