Description

5-Chloro-2-(Trifluoromethyl)-Dl-Phenylalanine is a specialized non-natural amino acid derivative featuring both chloro and trifluoromethyl substituents on the aromatic ring. This compound is valued for its role as a critical chiral building block and intermediate in advanced organic synthesis. It is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, process development, and the creation of novel bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in protease inhibitor and receptor antagonist programs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and combinatorial chemistry libraries to explore novel drug candidates.
• Agrochemical Synthesis: Serves as a building block for developing advanced herbicides, fungicides, and plant growth regulators that incorporate fluorine for enhanced activity and stability.
• Peptidomimetics Development: Incorporated into peptide analogs to modulate biological activity, stability, and pharmacokinetic properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and protein-ligand interactions.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale production of fine chemicals.

Basic Information

Product Name	5-Chloro-2-(Trifluoromethyl)-Dl-Phenylalanine
CAS No.	1256482-62-8
Molecular Formula	C10H9ClF3NO2
Molecular Weight	267.63 g/mol
Synonyms	DL-5-Chloro-2-(trifluoromethyl)phenylalanine; (±)-5-Chloro-α-amino-2-(trifluoromethyl)benzenepropanoic acid; 2-Amino-3-[5-chloro-2-(trifluoromethyl)phenyl]propanoic acid; 5-Chloro-2-trifluoromethyl-DL-phenylalanine; (RS)-5-Chloro-2-(trifluoromethyl)phenylalanine; 5-Chloro-α-amino-2-(trifluoromethyl)hydrocinnamic acid; Benzenepropanoic acid, 5-chloro-α-amino-2-(trifluoromethyl)-, (±)-
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-(Trifluoromethyl)-Dl-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via spectroscopic methods (NMR, IR, MS). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines for early-phase development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if opened for prolonged use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	DL-mixture (Racemic)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.