Description

(2,3,5-Trifluorophenyl)Acetic Acid Ethyl Ester is a high-purity fluorinated aromatic building block essential for advanced organic synthesis. This compound is valued for its role in introducing the (2,3,5-trifluorophenyl) moiety, a key structural motif that can significantly alter the physicochemical and biological properties of target molecules. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients, particularly where fine-tuning of lipophilicity, metabolic stability, and binding affinity is required.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially in drug discovery programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms enhance bioactivity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials, contributing to improved dielectric anisotropy and thermal stability.
• Advanced Polymer Chemistry: Employed to create specialty monomers for high-performance polymers with enhanced chemical resistance and unique optical properties.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D focused on organofluorine chemistry, cross-coupling reactions, and heterocycle formation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and complex molecules under cGMP or research-grade conditions.

Basic Information

Product Name	(2,3,5-Trifluorophenyl)Acetic Acid Ethyl Ester
CAS No.	1256479-84-1
Molecular Formula	C10H9F3O2
Molecular Weight	218.17 g/mol
Synonyms	Ethyl (2,3,5-Trifluorophenyl)acetate; 2-(2,3,5-Trifluorophenyl)acetic Acid Ethyl Ester; (2,3,5-Trifluorobenzene)acetic Acid Ethyl Ester; Ethyl 2-(2,3,5-Trifluorophenyl)acetate; Acetic Acid, 2-(2,3,5-Trifluorophenyl)-, Ethyl Ester; TL-1-179; ZINC000103014757; BCP33333
EINECS	Contact for details

Quality Control

Every batch of (2,3,5-Trifluorophenyl)Acetic Acid Ethyl Ester is manufactured and analyzed under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements of your synthetic application. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments. Our standard quality commitment aligns with research and development-grade specifications, with capabilities for custom synthesis under more stringent controls.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider using an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.