Description

2-(5-Butoxy-4-Chloro-2-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity, advanced boronic ester derivative, serving as a critical synthetic intermediate in modern organic chemistry. Its value lies in its exceptional utility as a key building block for constructing complex molecular architectures via cross-coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients and fine chemicals. The CAS number for this product is 1256360-19-6.

Application

This specialized boronic ester is a versatile reagent designed for high-value synthesis. Its primary applications include:

• Pharmaceutical Intermediates: A key building block in Suzuki-Miyaura cross-coupling reactions for synthesizing complex, fluorinated and chlorinated biaryl structures found in active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that leverage the unique properties of the fluorinated phenyl ring.
• Material Science: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics, where specific aryl-aryl linkages are required.
• Ligand & Catalyst Synthesis: Employed in the preparation of sophisticated ligands and organometallic catalysts for asymmetric synthesis and other catalytic processes.
• Chemical Biology & Diagnostics: Utilized as a probe or linker in bioconjugation chemistry for developing diagnostic tools and targeted therapies.

Basic Information

Product Name	2-(5-Butoxy-4-Chloro-2-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1256360-19-6
Molecular Formula	C16H23BClFO3
Molecular Weight	328.62 g/mol
Synonyms	5-Butoxy-4-chloro-2-fluorophenylboronic acid pinacol ester; (5-Butoxy-4-chloro-2-fluorophenyl)boronic acid pinacol ester; 4-Chloro-5-butoxy-2-fluorophenylboronic acid pinacol ester; (4-Chloro-5-butoxy-2-fluorophenyl)boronic acid pinacol ester; 2-Fluoro-4-chloro-5-butoxyphenylboronic acid pinacol ester; CAS 1256360-19-6; Pinacol (5-butoxy-4-chloro-2-fluorophenyl)boronate
EINECS	Contact for details

Quality Control

Our 2-(5-Butoxy-4-Chloro-2-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent hydrolysis of the boronic ester group.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.