Description

2-(4-Chloro-5-(Cyclopropylmethoxy)-2-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity, advanced pharmaceutical intermediate and key building block in modern synthetic chemistry. Its value lies in its role as a versatile boronic ester pinacol ester, enabling critical Suzuki-Miyaura cross-coupling reactions for constructing complex biaryl systems. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds containing complex fluorinated biaryl structures.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key boron reagent for forming carbon-carbon bonds between aryl halides and aryl boronic esters, a cornerstone of modern medicinal chemistry.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific fluorinated aromatic components.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where precise molecular architecture is required.
• Chemical Biology & Probe Development: Utilized as a building block for creating molecular probes and labeled compounds for diagnostic and research applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	2-(4-Chloro-5-(Cyclopropylmethoxy)-2-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1256360-17-4
Molecular Formula	C₁₆H₂₁BClFO₃
Molecular Weight	326.60 g/mol
Synonyms	4-Chloro-5-(cyclopropylmethoxy)-2-fluorophenylboronic acid pinacol ester; 2-Fluoro-4-chloro-5-(cyclopropylmethoxy)phenylboronic acid pinacol ester; (4-Chloro-5-(cyclopropylmethoxy)-2-fluorophenyl)boronic acid pinacol ester; Pinacol [4-chloro-5-(cyclopropylmethoxy)-2-fluorophenyl]boronate; B-[4-Chloro-5-(cyclopropylmethoxy)-2-fluorophenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; CAS 1256360-17-4
EINECS	Contact for details

Quality Control

Our production of 2-(4-Chloro-5-(Cyclopropylmethoxy)-2-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent performance for sensitive cross-coupling applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with client specifications and industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.