Description

4-Chloro-5-Ethoxy-2-Fluorophenylboronic Acid, Pinacol Ester is a high-purity, synthetically valuable organoboron building block. This compound is essential for modern cross-coupling reactions, enabling the efficient and precise construction of complex molecular architectures. It is primarily sought after by pharmaceutical, agrochemical, and advanced materials research and development teams for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used to construct complex heterocyclic cores found in modern herbicides, fungicides, and insecticides.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge transport materials.
• Ligand & Catalyst Development: Employed in the synthesis of specialized ligands for catalysis and molecular recognition applications.
• Chemical Biology Probes: Utilized to create tagged molecules for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical raw material for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	4-Chloro-5-Ethoxy-2-Fluorophenylboronic Acid, Pinacol Ester
CAS No.	1256360-15-2
Molecular Formula	C14H19BClFO3
Molecular Weight	300.56 g/mol
Synonyms	4-Chloro-5-ethoxy-2-fluorophenylboronic acid pinacol ester; (4-Chloro-5-ethoxy-2-fluorophenyl)boronic acid pinacol ester; 2-(4-Chloro-5-ethoxy-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-Chloro-5-ethoxy-2-fluorobenzeneboronic acid pinacol ester; Pinacol (4-chloro-5-ethoxy-2-fluorophenyl)boronate; CAS 1256360-15-2
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-5-Ethoxy-2-Fluorophenylboronic Acid, Pinacol Ester is manufactured under strict quality management systems. We employ advanced analytical techniques including NMR, HPLC, and GC to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.