Description

1,2-Dimethyl 4-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phthalate is a high-value, synthetically versatile organoboron building block, specifically a phthalate ester derivative containing a pinacol boronate ester functional group. Its core value lies in enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which is fundamental for constructing complex molecular architectures in advanced research and development. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise, high-purity intermediates for synthesizing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs) and drug candidates via palladium-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that incorporate fluorinated aromatic systems for enhanced efficacy and stability.
• Material Science Research: Serves as a precursor for creating fluorinated organic electronic materials, such as those used in OLEDs (Organic Light-Emitting Diodes) and semiconductors.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands and organometallic catalysts for asymmetric synthesis and other catalytic processes.
• Chemical Biology & Probe Development: Utilized to synthesize fluorinated molecular probes and tags for imaging, diagnostics, and studying biological mechanisms.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	1,2-Dimethyl 4-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phthalate
CAS No.	1256359-29-1
Molecular Formula	C₁₈H₂₄BFO₆
Molecular Weight	366.19 g/mol
Synonyms	Dimethyl 4-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phthalate; 4-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phthalic Acid Dimethyl Ester; 1,2-Dimethyl 4-Fluoro-5-(pinacolatoboron)phthalate; 5-Boronic acid, 4-fluoro-1,2-benzenedicarboxylic acid, 1,2-dimethyl ester, pinacol ester; (4-Fluoro-5-(methoxycarbonyl)-2-(methoxycarbonyl)phenyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Every batch of our 1,2-Dimethyl 4-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phthalate is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive cross-coupling chemistry and advanced synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles by NMR, HPLC, and GC are available upon request and with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.