Description

2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Trifluoromethoxy)Aniline is a high-value, multi-functional boronic ester derivative that serves as a critical building block in advanced organic synthesis. Its molecular structure, featuring both a protected boronic acid group and a reactive aniline moiety, makes it an indispensable intermediate for constructing complex molecules. This compound is primarily sought after by R&D and process development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing biaryl structures found in drug candidates targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used to introduce the trifluoromethoxyphenyl pharmacophore into novel herbicides, fungicides, and insecticides, enhancing their biological activity and metabolic stability.
• Material Science Research: Building block for creating organic electronic materials, such as charge-transport layers in OLEDs, due to its electron-deficient aromatic system.
• Ligand & Catalyst Development: The aniline nitrogen can be functionalized to create novel bidentate ligands for transition metal catalysis.
• Chemical Biology Probes: Utilized in the synthesis of activity-based probes and molecular tags for studying biological pathways and protein labeling.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and libraries for high-throughput screening.

Basic Information

Product Name	2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Trifluoromethoxy)Aniline
CAS No.	1256359-27-9
Molecular Formula	C13H17BF3NO3
Molecular Weight	303.09 g/mol
Synonyms	5-(Trifluoromethoxy)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline; 2-Amino-4-(trifluoromethoxy)phenylboronic acid pinacol ester; 5-(Trifluoromethoxy)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine; 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethoxy)phenylamine; 5-Trifluoromethoxy-2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenylamine; Aniline, 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethoxy)-; Pinacol [2-amino-4-(trifluoromethoxy)phenyl]boronate
EINECS	Contact for details

Quality Control

Our production of 2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Trifluoromethoxy)Aniline adheres to stringent quality management systems. Every batch undergoes comprehensive analytical characterization, including HPLC, NMR (1H, 13C, 19F, 11B), and GC/MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical specifications. Our quality commitment supports applications requiring regulatory filings under cGMP, ICH guidelines, and REACH compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent moisture absorption and decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.