Description

1-(4-Fluoro-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)Pyrrolidine is a high-purity, advanced pharmaceutical intermediate featuring a boronic ester pinacol group, making it a critical building block for modern synthetic chemistry. This compound is essential for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of novel active pharmaceutical ingredients (APIs), particularly in areas like oncology and central nervous system (CNS) therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially those containing biaryl structures.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the efficient formation of carbon-carbon bonds between aryl/heteroaryl halides and boronic acids/esters under mild conditions.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to develop new therapeutic molecules.
• Agrochemical Synthesis: Serves as a building block for creating novel herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science: Potential use in the development of organic electronic materials, such as OLEDs and semiconductors, through controlled polymerization.
• Chemical Biology Probes: Can be incorporated into molecules used to study biological processes and protein functions.

Basic Information

Product Name	1-(4-Fluoro-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)Pyrrolidine
CAS No.	1256359-05-3
Molecular Formula	C17H25BFNO2
Molecular Weight	305.20 g/mol
Synonyms	2-(4-Fluoro-2-(pyrrolidin-1-ylmethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 1-[(4-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methyl]pyrrolidine; 4-Fluoro-2-(pyrrolidin-1-ylmethyl)phenylboronic acid pinacol ester; (4-Fluoro-2-((pyrrolidin-1-yl)methyl)phenyl)boronic acid pinacol ester; CAS 1256359-05-3
EINECS	Contact for details

Quality Control

Our 1-(4-Fluoro-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)Pyrrolidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent chemical identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and cGMP-grade production for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. For long-term storage, keep under an inert atmosphere (e.g., nitrogen or argon) at temperatures between 2°C and 8°C to maintain stability. The compound is moisture-sensitive; ensure containers are sealed tightly after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.