Description

2-Chloro-4-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is a high-purity, multi-functional boronic ester derivative, serving as a critical building block in modern synthetic chemistry. Its value lies in enabling precise carbon-carbon and carbon-heteroatom bond formation, which is essential for constructing complex molecular architectures. This advanced intermediate is primarily needed by researchers and manufacturers in the pharmaceutical and agrochemical industries for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing active pharmaceutical ingredients (APIs), especially in kinase inhibitor and other small-molecule drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents, herbicides, and fungicides that require the specific pyridine-boronate scaffold.
• Material Science Research: Employed in the development of organic electronic materials, such as ligands for OLEDs or charge-transport materials, due to its electron-deficient pyridine core and boronate functionality.
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and the synthesis of molecular probes and inhibitors for target identification and validation.
• Fine Chemical Manufacturing: Serves as a specialized building block for custom synthesis and contract manufacturing of complex, high-value organic compounds.

Basic Information

Product Name	2-Chloro-4-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
CAS No.	1256359-04-2
Molecular Formula	C11H14BClFNO2
Molecular Weight	255.50 g/mol
Synonyms	2-Chloro-4-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 5-(2-Chloro-4-fluoropyridin-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2-Chloro-4-fluoro-5-pyridineboronic acid pinacol ester; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-chloro-4-fluoropyridine; 2-Chloro-4-fluoro-5-(pinacolboryl)pyridine; Pyridine, 2-chloro-4-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 1256359-04-2; 2-Cl-4-F-5-PyridineBpin
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Products undergo rigorous analytical testing, including HPLC, NMR, and GC-MS, to confirm identity, potency, and impurity profiles. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.