Description

4-(4-Chloro-2-Fluorophenoxy)Phenylboronic Acid is a specialized boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in its ability to participate in key cross-coupling reactions, enabling the efficient construction of complex molecular architectures. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing new active ingredients and advanced materials.

Application

This compound is primarily utilized as a versatile synthetic intermediate. Its key applications include:

• Suzuki-Miyaura Cross-Coupling Reactions: A fundamental reagent for forming carbon-carbon bonds in the synthesis of biaryl structures, a common motif in many drug molecules.
• Pharmaceutical Research & Development: Used in the discovery and process development of new active pharmaceutical ingredients (APIs), especially those containing complex aromatic and heteroaromatic systems.
• Agrochemical Synthesis: Serves as a key precursor in the manufacturing of advanced herbicides, fungicides, and insecticides.
• Material Science: Employed in the synthesis of organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Ligand and Catalyst Preparation: Useful for creating novel boron-containing ligands for catalytic systems.
• Chemical Biology: Can be used in the development of probes and inhibitors for biochemical research.

Basic Information

Product Name	4-(4-Chloro-2-Fluorophenoxy)Phenylboronic Acid
CAS No.	1256358-57-2
Molecular Formula	C12H9BClFO3
Molecular Weight	265.46 g/mol
Synonyms	[4-(4-Chloro-2-fluorophenoxy)phenyl]boronic acid; B-[4-(4-Chloro-2-fluorophenoxy)phenyl]boronic acid; 4-(4-Chloro-2-fluorophenoxy)benzeneboronic acid; (4-(4-Chloro-2-fluorophenoxy)phenyl)boronic acid; Boronic acid, B-[4-(4-chloro-2-fluorophenoxy)phenyl]-; 4-Chloro-2-fluoro-4'-boronic acid diphenyl ether
EINECS	Contact for details

Quality Control

Our 4-(4-Chloro-2-Fluorophenoxy)Phenylboronic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, essential for sensitive cross-coupling reactions. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality systems are designed to meet the stringent requirements of pharmaceutical R&D and GMP starting material guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.