Description

3-(2-Chloro-4-Fluorophenylmethoxy)Phenylboronic Acid is a high-purity, functionalized boronic acid derivative designed for advanced synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the precise construction of complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds between aryl halides and boronic acids, essential for creating biaryl structures in drug discovery.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system and metabolic diseases.
• Agrochemical Synthesis: Employed in the production of advanced herbicides and fungicides, where the specific halogen and ether substitutions offer unique biological activity.
• Material Science Research: Acts as a monomer or functionalization agent in the development of organic electronic materials, such as polymers for OLEDs.
• Chemical Biology Probes: Utilized to synthesize molecules for studying biological pathways and protein interactions due to its specific reactivity profile.

Basic Information

Product Name	3-(2-Chloro-4-Fluorophenylmethoxy)Phenylboronic Acid
CAS No.	1256358-45-8
Molecular Formula	C13H11BClFO3
Molecular Weight	279.49 g/mol
Synonyms	[2-Chloro-4-fluoro(phenylmethoxy)]benzeneboronic acid; (3-[(2-Chloro-4-fluorobenzyl)oxy]phenyl)boronic acid; 3-[(2-Chloro-4-fluorobenzyl)oxy]benzeneboronic acid; Boronic acid, B-[3-[(2-chloro-4-fluorophenyl)methoxy]phenyl]-; 3-(2-Chloro-4-fluorobenzyloxy)phenylboronic acid; 2-Chloro-4-fluoro-3-methoxybenzeneboronic acid (related isomer); BBN-3-COF
EINECS	Contact for details

Quality Control

Our 3-(2-Chloro-4-Fluorophenylmethoxy)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.